Roles of F-box proteins in cancer

Zhiwei Wang, Pengda Liu, Hiroyuki Inuzuka, Wenyi Wei

Research output: Contribution to journalReview articlepeer-review

332 Citations (Scopus)


F-box proteins, which are the substrate-recognition subunits of SKP1-cullin 1-F-box protein (SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through ubiquitylation and subsequent degradation of target proteins. Dysregulation of F-box protein-mediated proteolysis leads to human malignancies. Notably, inhibitors that target F-box proteins have shown promising therapeutic potential, urging us to review the current understanding of how F-box proteins contribute to tumorigenesis. As the physiological functions for many of the 69 putative F-box proteins remain elusive, additional genetic and mechanistic studies will help to define the role of each F-box protein in tumorigenesis, thereby paving the road for the rational design of F-box protein-targeted anticancer therapies.

Original languageEnglish
Pages (from-to)233-247
Number of pages15
JournalNature Reviews Cancer
Issue number4
Publication statusPublished - 2014 Apr
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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