TY - JOUR
T1 - Roles of F-box proteins in cancer
AU - Wang, Zhiwei
AU - Liu, Pengda
AU - Inuzuka, Hiroyuki
AU - Wei, Wenyi
N1 - Funding Information:
The authors sincerely apologize to all those colleagues whose important work was not cited in this paper owing to space limitations. They thank B. North, A. W. Lau, S. Shaik and other members of the Wei laboratory for critical reading and discussion of the manuscript. W.W. is an American Cancer Society (ACS) research scholar and a Leukemia & Lymphoma Society (LLS) research scholar. P.L. is supported by grant 5T32HL007893. H.I. is supported by grant AG041218. This work was supported by a grant from the National Natural Science Foundation of China (NSFC) (81172087) and the Priority Academic Program Development of Jiangsu Higher Education Institutions. This work was supported in part by US National Institutes of Health (NIH) grants to W.W. (GM089763, GM094777 and CA177910).
PY - 2014/4
Y1 - 2014/4
N2 - F-box proteins, which are the substrate-recognition subunits of SKP1-cullin 1-F-box protein (SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through ubiquitylation and subsequent degradation of target proteins. Dysregulation of F-box protein-mediated proteolysis leads to human malignancies. Notably, inhibitors that target F-box proteins have shown promising therapeutic potential, urging us to review the current understanding of how F-box proteins contribute to tumorigenesis. As the physiological functions for many of the 69 putative F-box proteins remain elusive, additional genetic and mechanistic studies will help to define the role of each F-box protein in tumorigenesis, thereby paving the road for the rational design of F-box protein-targeted anticancer therapies.
AB - F-box proteins, which are the substrate-recognition subunits of SKP1-cullin 1-F-box protein (SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through ubiquitylation and subsequent degradation of target proteins. Dysregulation of F-box protein-mediated proteolysis leads to human malignancies. Notably, inhibitors that target F-box proteins have shown promising therapeutic potential, urging us to review the current understanding of how F-box proteins contribute to tumorigenesis. As the physiological functions for many of the 69 putative F-box proteins remain elusive, additional genetic and mechanistic studies will help to define the role of each F-box protein in tumorigenesis, thereby paving the road for the rational design of F-box protein-targeted anticancer therapies.
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U2 - 10.1038/nrc3700
DO - 10.1038/nrc3700
M3 - Review article
C2 - 24658274
AN - SCOPUS:84897085768
VL - 14
SP - 233
EP - 247
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
SN - 1474-175X
IS - 4
ER -
