TY - JOUR
T1 - Roles of Apicomplexan protein kinases at each life cycle stage
AU - Kato, Kentaro
AU - Sugi, Tatsuki
AU - Iwanaga, Tatsuya
N1 - Funding Information:
This study was supported by a JSPS Research Fellowship for Young Scientists and a grant-in-Aid for Young Scientists from the Ministry of Education, Culture, Science, Sports, and Technology (MEXT) of Japan , and Bio-oriented Technology Research Advancement Institution (BRAIN) , and the Mochida Memorial Foundation for Medical and Pharmaceutical Research .
PY - 2012/6
Y1 - 2012/6
N2 - Inhibitors of cellular protein kinases have been reported to inhibit the development of Apicomplexan parasites, suggesting that the functions of protozoan protein kinases are critical for their life cycle. However, the specific roles of these protein kinases cannot be determined using only these inhibitors without molecular analysis, including gene disruption. In this report, we describe the functions of Apicomplexan protein kinases in each parasite life stage and the potential of pre-existing protein kinase inhibitors as Apicomplexan drugs against, mainly, Plasmodium and Toxoplasma.
AB - Inhibitors of cellular protein kinases have been reported to inhibit the development of Apicomplexan parasites, suggesting that the functions of protozoan protein kinases are critical for their life cycle. However, the specific roles of these protein kinases cannot be determined using only these inhibitors without molecular analysis, including gene disruption. In this report, we describe the functions of Apicomplexan protein kinases in each parasite life stage and the potential of pre-existing protein kinase inhibitors as Apicomplexan drugs against, mainly, Plasmodium and Toxoplasma.
KW - Apicomplexan protein kinase
KW - Life cycle
KW - Plasmodium
KW - Protein kinase inhibitor
KW - Toxoplasma
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U2 - 10.1016/j.parint.2011.12.002
DO - 10.1016/j.parint.2011.12.002
M3 - Review article
C2 - 22209882
AN - SCOPUS:84857801309
VL - 61
SP - 224
EP - 234
JO - Parasitology International
JF - Parasitology International
SN - 1383-5769
IS - 2
ER -