Roles of Apicomplexan protein kinases at each life cycle stage

Kentaro Kato, Tatsuki Sugi, Tatsuya Iwanaga

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Inhibitors of cellular protein kinases have been reported to inhibit the development of Apicomplexan parasites, suggesting that the functions of protozoan protein kinases are critical for their life cycle. However, the specific roles of these protein kinases cannot be determined using only these inhibitors without molecular analysis, including gene disruption. In this report, we describe the functions of Apicomplexan protein kinases in each parasite life stage and the potential of pre-existing protein kinase inhibitors as Apicomplexan drugs against, mainly, Plasmodium and Toxoplasma.

Original languageEnglish
Pages (from-to)224-234
Number of pages11
JournalParasitology International
Volume61
Issue number2
DOIs
Publication statusPublished - 2012 Jun 1
Externally publishedYes

Keywords

  • Apicomplexan protein kinase
  • Life cycle
  • Plasmodium
  • Protein kinase inhibitor
  • Toxoplasma

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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