Role of the nrf-2 gene in protection and repair of gastric mucosa against oxidative stress

A. Yanaka, S. Zhang, M. Tauchi, H. Suzuki, T. Shibahara, H. Matsui, A. Nakahara, N. Tanaka, M. Yamamoto

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)

Abstract

Helicobacter pylori infection, as well as NSAIDs induce oxidative stress on gastric mucosa, thereby causing mucosal damage and retarding mucosal repair. Cells can survive against chronic oxidative stress by enhancing activities of anti-oxidant enzymes, thereby protecting cells from DNA damage. Recent studies have clearly shown that the gene encoding Nrf-2 (NF-E2 p45-related factor-2) plays an important role in the induction of antioxidant enzymes against oxidative stress. In this paper, we will describe the cellular mechanisms by which the nrf-2 gene stimulates anti-oxidant enzyme activities during exposure to oxidative stress. Secondly, we will also mention the beneficial effects of sulforaphane, an isothiocyanate family which is abundantly included in broccoli sprouts, on gastric mucosa. Sulforaphane stimulates nrf-2 gene-dependent anti-oxidant enzyme activities, thereby protecting cells from oxidative injury. Finally, we will state our perspective on the efficacy of sulforaphane in protection and repair of gastric mucosa against oxidative stress during H. pylori infection.

Original languageEnglish
Pages (from-to)83-90
Number of pages8
JournalInflammopharmacology
Volume13
Issue number1-3
DOIs
Publication statusPublished - 2005 Nov 21
Externally publishedYes

Keywords

  • Anti-oxidant
  • Free radical
  • Knockout mice
  • Sulforaphane
  • Ussing chamber

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Pharmacology (medical)

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