TY - JOUR
T1 - Role of the nrf-2 gene in protection and repair of gastric mucosa against oxidative stress
AU - Yanaka, A.
AU - Zhang, S.
AU - Tauchi, M.
AU - Suzuki, H.
AU - Shibahara, T.
AU - Matsui, H.
AU - Nakahara, A.
AU - Tanaka, N.
AU - Yamamoto, M.
PY - 2005/11/21
Y1 - 2005/11/21
N2 - Helicobacter pylori infection, as well as NSAIDs induce oxidative stress on gastric mucosa, thereby causing mucosal damage and retarding mucosal repair. Cells can survive against chronic oxidative stress by enhancing activities of anti-oxidant enzymes, thereby protecting cells from DNA damage. Recent studies have clearly shown that the gene encoding Nrf-2 (NF-E2 p45-related factor-2) plays an important role in the induction of antioxidant enzymes against oxidative stress. In this paper, we will describe the cellular mechanisms by which the nrf-2 gene stimulates anti-oxidant enzyme activities during exposure to oxidative stress. Secondly, we will also mention the beneficial effects of sulforaphane, an isothiocyanate family which is abundantly included in broccoli sprouts, on gastric mucosa. Sulforaphane stimulates nrf-2 gene-dependent anti-oxidant enzyme activities, thereby protecting cells from oxidative injury. Finally, we will state our perspective on the efficacy of sulforaphane in protection and repair of gastric mucosa against oxidative stress during H. pylori infection.
AB - Helicobacter pylori infection, as well as NSAIDs induce oxidative stress on gastric mucosa, thereby causing mucosal damage and retarding mucosal repair. Cells can survive against chronic oxidative stress by enhancing activities of anti-oxidant enzymes, thereby protecting cells from DNA damage. Recent studies have clearly shown that the gene encoding Nrf-2 (NF-E2 p45-related factor-2) plays an important role in the induction of antioxidant enzymes against oxidative stress. In this paper, we will describe the cellular mechanisms by which the nrf-2 gene stimulates anti-oxidant enzyme activities during exposure to oxidative stress. Secondly, we will also mention the beneficial effects of sulforaphane, an isothiocyanate family which is abundantly included in broccoli sprouts, on gastric mucosa. Sulforaphane stimulates nrf-2 gene-dependent anti-oxidant enzyme activities, thereby protecting cells from oxidative injury. Finally, we will state our perspective on the efficacy of sulforaphane in protection and repair of gastric mucosa against oxidative stress during H. pylori infection.
KW - Anti-oxidant
KW - Free radical
KW - Knockout mice
KW - Sulforaphane
KW - Ussing chamber
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U2 - 10.1163/156856005774423863
DO - 10.1163/156856005774423863
M3 - Review article
C2 - 16259730
AN - SCOPUS:27744570897
VL - 13
SP - 83
EP - 90
JO - Inflammopharmacology
JF - Inflammopharmacology
SN - 0925-4692
IS - 1-3
ER -