Role of SLAM-associated protein in the pathogenesis of autoimmune diseases and immunological disorders

Hiroshi Furukawa, Shigeto Tohma, Hiroshi Kitazawa, Hiroaki Komori, Masato Nose, Masao Ono

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)


Signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is an adaptor molecule containing a Src homology 2 (SH2) domain. SAP is expressed in T cells and natural killer (NK) cells and binds to the cytoplasmic domains of SLAM family receptors, resulting in the subsequent recruitment of Fyn. The SAP (SH2D1A) gene is located on the X chromosome and is responsible for X-linked lymphoproliferative disease, characterized by higher susceptibility to Epstein-Barr virus infection. The SAP-mediated signal is not only essential for the development of NKT cells, i.e. unconventional CD1d-restricted T cells with invariant Vα14 T cell receptors, but also for the regulation of the function of NK cells and conventional T cells. The role of SAP-mediated signaling in the induction of autoimmune diseases has been analyzed using animal models such as lupus, hepatitis, and graft-versus-host disease and is considered important in their pathogenesis in humans. In this review we highlight the current findings on SAP-mediated signaling in hematopoietic cells and discuss its importance in autoimmune diseases and immunological disorders.

Original languageEnglish
Pages (from-to)37-44
Number of pages8
JournalArchivum Immunologiae et Therapiae Experimentalis
Issue number1
Publication statusPublished - 2010 Feb
Externally publishedYes


  • Autoimmune diseases
  • SAP
  • SLAM

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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