Role of prolyl isomerase Pin1 in pathogenesis of diseases and remedy for the diseases from natural products

Katsuhiko Takahashi, Taiki Shimizu, Keita Kosaka, Masafumi Hidaka, Chiyoko Uchida, Takafumi Uchida

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The peptidyl prolyl cis/trans isomerase Pin1, the human ortholog of yeast Ess1 specifically isomerizes peptide bindings of pSer/pThr-Pro residues in various proteins, and regulates the expression levels and functions of phosphorylated proteins. Activation of Pin1 is associated with pathology of a variety of diseases, such as cancer, Alzheimer’s disease, infectious diseases and so on. Therefore, regulatory compounds for Pin1 can be applied as a clinical medicine against these diseases. Many chemists have exerted themselves to synthesize the inhibitors based on the 3D structure of Pin1. We have screened for the inhibitors against Pin1 from the natural products including the functional foods. Here we review the Pin1-associated pathology and the known inhibitors identified from natural products. And we introduce the screening methods targeting Pin1 activity.

Original languageEnglish
Pages (from-to)973-981
Number of pages9
JournalCurrent Drug Targets
Volume15
Issue number10
Publication statusPublished - 2014 Jan 1

Keywords

  • Inhibitor
  • Natural products
  • Pin1
  • Screening

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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