Role of peroxiredoxin III in the pathogenesis of pre-eclampsia as evidenced in mice

Lianqin Li, Masuo Obinata, Katsuyoshi Hori

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

As a member of peroxiredoxin (Prx) family, PrxIII has been demonstrated to play an important role in scavenging intracellular reactive oxygen species (ROS). Since PrxIII knockout mice exhibited oxidative stress in placentas resembling pathophysiologic changes in placentas of human pre-eclampsia, we measured blood pressure through the carotid artery and detected oxidative status by western blotting in pregnant mice. We did not notice hypertension in pregnant PrxIII knockout mice as compared with wild-type littermates, although endothelin-1 was overexpressed in PrxIII-deficient placentas. Our results indicate that PrxIII is not involved in pre-eclamptic development. Instead, PrxIII is an indispensable antioxidant in placentas where oxidative stress exists.

Original languageEnglish
Pages (from-to)71-73
Number of pages3
JournalOxidative Medicine and Cellular Longevity
Volume3
Issue number1
DOIs
Publication statusPublished - 2010

Keywords

  • Hypertension
  • Mouse
  • Oxidative stress
  • Peroxiredoxin
  • Placenta
  • Pre-eclampsia
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Cell Biology

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