Role of paraxial mesoderm in limb/flank regionalization of the trunk lateral plate

Miyuki Noro, Hiroki Yuguchi, Taeko Sato, Takanobu Tsuihiji, Sayuri Yonei-Tamura, Hitoshi Yokoyama, Yoshio Wakamatsu, Koji Tamura

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

To understand the developmental mechanism that determines limb size and the consequent limb-to-trunk proportions in the tetrapod body, we investigated the role of the paraxial mesoderm in the specification of the limb and flank fields in the chick embryo. We found that the paraxial mesoderm subjacent to the limb field can affect the size of the limb bud along the anterior-posterior and proximal-distal axes. We also found that the paraxial mesoderm subjacent to the flank plays roles in suppressing the emergence and growth of the limb bud and in promoting flank-specific apoptosis in the lateral plate mesoderm. Our results suggest that signals from the paraxial mesoderm specify the limb and flank fields in the competent lateral plate mesoderm.

Original languageEnglish
Pages (from-to)1639-1649
Number of pages11
JournalDevelopmental Dynamics
Volume240
Issue number7
DOIs
Publication statusPublished - 2011 Jul

Keywords

  • Apoptosis
  • Competence
  • Evolution
  • Flank
  • Gnathostome
  • Limb
  • Paraxial mesoderm
  • Presomitic mesoderm

ASJC Scopus subject areas

  • Developmental Biology

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