Role of osteoclast in preferential alignment of biological apatite (BAp) in long bones

Jee Wook Lee, Takayoshi Nakano, Satoru Toyosawa, Naokuni Ijuhin, Yasuhiko Tabata, Masaya Yamamoto, Yukichi Umakoshi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Citations (Scopus)

Abstract

Absorption and formation of hard tissues are repeated in vivo by the activity of osteoclast and osteoblast, respectively. The preferential alignment of BAp or collagen fibril is thought to be closely related to the activity of the bone cells. In this study, changes in bone mineral density (BMD) and preferential alignment of biological apatite (BAp) were examined focusing on the role of osteoblast using the model of osteopetrotic (op/op) mice in which osteoblast activity was normal but the expression of osteoclast was reduced. Osteopetrotic (op/op) mice and their normal littermates aged 5, 12 and 24 weeks were analyzed. The BMD and BAp texture of femoral diaphysis were measured using peripheral quantitative computed tomography (pQCT) and a microbeam X-ray diffractometer system with a 50 μmφ diameter beam spot respectively. The decrease in osteoclast expression induced both the reduction of the skeletal system and calcification of the medullary cavity, which are typical features of osteopetrosis. As a result, the shape, BMD and preferential BAp alignment of the femur in the op/op mice were remarkably different from those in the control group. At the center of the femoral diaphysis, BMD in the cortical area showed no significant difference between the two groups, but preferential alignment of the BAp c-axis in the op/op mice group had a lower value than that in the control group. This suggests that the decrease in the number of osteoclasts suppresses normal remodeling, resulting in a decrease in bone quality, especially the preferential alignment of the BAp c-axis.

Original languageEnglish
Title of host publicationAdvanced Structural and Functional Materials Design - Proceedings of the International Symposium on Advanced Structural and Functional Materials Design, 2004
PublisherTrans Tech Publications Ltd
Pages265-268
Number of pages4
ISBN (Print)0878499962, 9780878499960
DOIs
Publication statusPublished - 2006 Jan 1
Externally publishedYes
EventInternational Symposium on Advanced Structural and Functional Materials Design, 2004 - Osaka, Japan
Duration: 2004 Nov 102004 Nov 12

Publication series

NameMaterials Science Forum
Volume512
ISSN (Print)0255-5476
ISSN (Electronic)1662-9752

Other

OtherInternational Symposium on Advanced Structural and Functional Materials Design, 2004
CountryJapan
CityOsaka
Period04/11/1004/11/12

Keywords

  • BMD
  • Biological apatite
  • Oseteoblast
  • Osteoclast
  • Osteopetrotic mice (op/op)
  • Preferential alignment
  • Remodeling

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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    Lee, J. W., Nakano, T., Toyosawa, S., Ijuhin, N., Tabata, Y., Yamamoto, M., & Umakoshi, Y. (2006). Role of osteoclast in preferential alignment of biological apatite (BAp) in long bones. In Advanced Structural and Functional Materials Design - Proceedings of the International Symposium on Advanced Structural and Functional Materials Design, 2004 (pp. 265-268). (Materials Science Forum; Vol. 512). Trans Tech Publications Ltd. https://doi.org/10.4028/0-87849-996-2.265