Role of nitric oxide in adrenal catecholamine secretion in anesthetized dogs

Takahiro Nagayama, Akio Hosokawa, Makoto Yoshida, Mizue Suzuki-Kusaba, Hiroaki Hisa, Tomohiko Kimura, Susumu Satoh

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

We examined the role of nitric oxide (NO) in adrenal catecholamine secretion in response to splanchnic nerve stimulation (SNS) and exogenous acetylcholine (ACh) in anesthetized dogs. The NO synthase inhibitor N(ω)- nitro-Larginine methyl ester (L-NAME), NO donor 3-(2-hydroxy-1-methyl-2- nitrosohydrazino)-N-methyl-l-propanamine (NOC 7), and ACh were administered intra-arterially into the adrenal gland. The increases in catecholamine output induced by ACh (0.75-3 μg) were enhanced by L-NAME (0.1-1 mg/min) and inhibited by NOC 7 (0.2-2 μg/min). Inhibition by NOC 7 (2 μg/min) was observed during treatment with L-NAME (1 mg/min). The increases in catecholamine output induced by SNS (1-2 Hz) were inhibited by L-NAME and by NOC 7. No inhibitory effect of NOC 7 was observed during treatment with L- NAME. These results suggest that NO may play an inhibitory role in the regulation of adrenal catecholamine secretion in response to exogenous ACh.

Original languageEnglish
Pages (from-to)R1075-R1081
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume275
Issue number4 44-4
Publication statusPublished - 1998 Oct 1

Keywords

  • 3-(2-hydroxy-1- methyl-2-nitrosohydrazino)-N-methyl-1-propanamine
  • Acetylcholine
  • Adrenal gland
  • N(ω)-nitro-L-arginine methyl ester
  • Splanchnic nerve stimulation

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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