Role of natural killer T cells in host defence against cryptococcal infection

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4 Citations (Scopus)

Abstract

Cryptococcosis is an opportunistic fungal infectious disease that often occurs in severely immunocompromised patients. Host defence against the causative microorganism is largely mediated by cellular immunity, and Th1 cytokines, such as IFN-γ, play central roles in the host protective responses. IL-12 and IL-18 activate the synthesis of IFN-γ by innate immune cells, including NK, NKT and γδ T cells and promote the differentiation of Th1-type acquired immune responses. Recently, NKT cells, which are involved in the recognition of glycolipid antigens, have attracted much attention based on their potent immunomodulating activities. Several studies have reported the role of this particular component of innate immune responses in tumor immunity and pathogenesis of autoimmune diseases. In this review, I outline the recent findings on the role of NKT cells in host defence against infectious microorganisms, with a special focus on our data emphasizing the importance of this subset of immunocytes in the development of acquired as well as early host protection against cryptococcal infection.

Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalRevista Iberoamericana de Micologia
Volume19
Issue number3
Publication statusPublished - 2002 Sep 1
Externally publishedYes

Keywords

  • Cryptococcosis
  • Host defence
  • NKT cells

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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