Role of Na+ -glucose cotransport in fluid absorption across alveolar epithelium in isolated rat lungs

S. Suzuki, Masafumi Noda, M. Sugita, T. Tanita, S. Ono, T. Sakuma, K. Koike, S. Fujimura

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

To evaluate the role of Na+-glucose cotransport in fluid absorption across alveolar epithelial walls in isolated rat lungs, we measured the inhibitory effect of amiloride (a Na+ channel blocker) and phlorizin (a Na+-glucose cotransport blocker) on the fluid absorption rate in fluid- filled lungs. Amiloride (10-5 - 10-4 M) reduced alveolar fluid absorption by 30%. This value was similar to that obtained in the presence of 10-3 M phlorizin. The coefficient of Na+-glucose cotransport was estimated to be 2.5. The strong correlation between Na+ escape and fluid absorption (r = 0.907) was not affected by phlorizin. These findings suggest that the impact of Na+-glucose cotransport was similar to that of Na+ transport alone, and that glucose molecules transported by Na+-glucose do not play an important role in alveolar fluid absorption across rat alveolar epithelium.

Original languageEnglish
Pages (from-to)1109-1114
Number of pages6
JournalJapanese Journal of Thoracic Diseases
Volume34
Issue number10
Publication statusPublished - 1996 Dec 7

Keywords

  • Alveolar epithelium
  • Na -glucose cotransport
  • Na channel
  • Phlorizin
  • Pulmonary edema

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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