Role of mitochondrial dysfunction in Alzheimer's disease

Rudy Castellani, Keisuke Hirai, Gjumrakch Aliev, Kelly L. Drew, Akihiko Nunomura, Atsushi Takeda, Adam D. Cash, Mark E. Obrenovich, George Perry, Mark A. Smith

Research output: Contribution to journalReview articlepeer-review

269 Citations (Scopus)

Abstract

Abnormalities in mitochondrial function relate to the spectrum of pathological changes seen in Alzheimer's disease. Here we review the causes and consequences of mitochondrial disturbances in Alzheimer's disease as well as how this information might impact on therapeutic approaches to this disease.

Original languageEnglish
Pages (from-to)357-360
Number of pages4
JournalJournal of Neuroscience Research
Volume70
Issue number3
DOIs
Publication statusPublished - 2002 Nov 2

Keywords

  • Alzheimer's disease
  • Mitochondria
  • Oxidative stress

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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