Role of histone methylation and demethylation in adipogenesis and obesity

Masashi Okamura, Takeshi Inagaki, Toshiya Tanaka, Juro Sakai

Research output: Contribution to journalReview articlepeer-review

72 Citations (Scopus)

Abstract

Adipocyte differentiation is a complex developmental process that involves the coordinated interplay of numerous transcription factors. PPARγ has emerged as a master regulator of adipogenesis and recent global target gene analysis demonstrated that PPARγ targets many genes encoding chromatin modification enzymes as well as genes of lipid metabolism and storage. Among such modification enzymes are histone lysine methyltransferases, which play important roles in transcriptional regulation. Histone methyltransferases are involved in PPARγ gene expression and subsequent adipogenesis. In addition, recent studies revealed that demethylation of histone H3 at lys9 is associated with resistance to obesity. We here review the role of histone methylation and demethylation in adipogenesis, metabolism and obesity.

Original languageEnglish
Pages (from-to)24-32
Number of pages9
JournalOrganogenesis
Volume6
Issue number1
DOIs
Publication statusPublished - 2010

Keywords

  • Adipogenesis
  • Epigenetics
  • Histone lysine methyltransferase (HKMT)
  • Metabolic syndrome
  • Obesity
  • PR-Set7
  • Peroxisome proliferator-activated receptor (PPAR)
  • Setd8
  • Setdb1
  • Wnt

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology
  • Developmental Biology
  • Transplantation

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