Role of histamine produced by bone marrow-derived vascular cells in pathogenesis of atherosclerosis

Yasuyuki Sasaguri, Ke Yong Wang, Akihide Tanimoto, Masato Tsutsui, Hikaru Ueno, Yoshitaka Murata, Yukari Kohno, Sohsuke Yamada, Hiroshi Ohtsu

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)


To clarify the role of histamine-producing cells and its origin in atherosclerosis, we investigated histidine decarboxylase (HDC; histamine-producing enzyme) expression in murine arteries with vascular injuries after the animal had received transplanted bone marrow (BM) from green fluorescent protein (GFP)-transgenic mice. The neointima in the ligated carotid arteries contained BM-derived HDC+ cells that expressed macrophage (Mac-3) or smooth muscle cell antigen (α-SMA). In contrast, the HDC + BM-derived cells, which were positive for Mac-3, were mainly located in the adventitia in the cuff replacement model. In apolipoprotein E-knockout mice on a high cholesterol diet, BM-derived cells expressing Mac-3 in the atheromatous plaques were also positive for HDC. In comparison with wild-type mice, HDC-/- mice showed reduced neointimal thickening and a decreased intima-to-media ratio after ligation and cuff replacement. These results indicate that histamine produced from BM-derived progenitor cells, which could transdifferentiate into SMC- or macrophage-like cells, are important for the formation of neointima and atheromatous plaques.

Original languageEnglish
Pages (from-to)974-981
Number of pages8
JournalCirculation research
Issue number9
Publication statusPublished - 2005 Mar 13
Externally publishedYes


  • Bone marrow
  • Histamine
  • Histidine decarboxylase
  • Progenitor cells
  • Vascular injury

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


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