Role of histamine H3 receptor in glucagon-secreting αTC1.6 cells

Tadaho Nakamura, Takeo Yoshikawa, Fumito Naganuma, Attayeb Mohsen, Tomomitsu Iida, Yamato Miura, Akira Sugawara, Kazuhiko Yanai

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Pancreatic α-cells secrete glucagon to maintain energy homeostasis. Although histamine has an important role in energy homeostasis, the expression and function of histamine receptors in pancreatic α-cells remains unknown. We found that the histamine H3 receptor (H3R) was expressed in mouse pancreatic α-cells and αTC1.6 cells, a mouse pancreatic α-cell line. H3R inhibited glucagon secretion from αTC1.6 cells by inhibiting an increase in intracellular Ca2+ concentration. We also found that immepip, a selective H3R agonist, decreased serum glucagon concentration in rats. These results suggest that H3R modulates glucagon secretion from pancreatic α-cells.

Original languageEnglish
Pages (from-to)36-41
Number of pages6
JournalFEBS Open Bio
Publication statusPublished - 2015


  • Glucagon secretion
  • Histamine H receptor
  • Pancreatic α-cells
  • αTC1.6 cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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