Role of histamine H3 receptor in glucagon-secreting αTC1.6 cells

Tadaho Nakamura; Takeo Yoshikawa; Fumito Naganuma; Attayeb Mohsen; Tomomitsu Iida; Yamato Miura; Akira Sugawara; Kazuhiko Yanai

doi:10.1016/j.fob.2014.12.001

Role of histamine H₃ receptor in glucagon-secreting αTC1.6 cells

Tadaho Nakamura, Takeo Yoshikawa, Fumito Naganuma, Attayeb Mohsen, Tomomitsu Iida, Yamato Miura, Akira Sugawara, Kazuhiko Yanai

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Pancreatic α-cells secrete glucagon to maintain energy homeostasis. Although histamine has an important role in energy homeostasis, the expression and function of histamine receptors in pancreatic α-cells remains unknown. We found that the histamine H₃ receptor (H₃R) was expressed in mouse pancreatic α-cells and αTC1.6 cells, a mouse pancreatic α-cell line. H₃R inhibited glucagon secretion from αTC1.6 cells by inhibiting an increase in intracellular Ca²⁺ concentration. We also found that immepip, a selective H₃R agonist, decreased serum glucagon concentration in rats. These results suggest that H₃R modulates glucagon secretion from pancreatic α-cells.

Original language	English
Pages (from-to)	36-41
Number of pages	6
Journal	FEBS Open Bio
Volume	5
DOIs	https://doi.org/10.1016/j.fob.2014.12.001
Publication status	Published - 2015

Keywords

Glucagon secretion
Histamine H receptor
Pancreatic α-cells
αTC1.6 cells

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.fob.2014.12.001

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title = "Role of histamine H3 receptor in glucagon-secreting αTC1.6 cells",

abstract = "Pancreatic α-cells secrete glucagon to maintain energy homeostasis. Although histamine has an important role in energy homeostasis, the expression and function of histamine receptors in pancreatic α-cells remains unknown. We found that the histamine H3 receptor (H3R) was expressed in mouse pancreatic α-cells and αTC1.6 cells, a mouse pancreatic α-cell line. H3R inhibited glucagon secretion from αTC1.6 cells by inhibiting an increase in intracellular Ca2+ concentration. We also found that immepip, a selective H3R agonist, decreased serum glucagon concentration in rats. These results suggest that H3R modulates glucagon secretion from pancreatic α-cells.",

keywords = "Glucagon secretion, Histamine H receptor, Pancreatic α-cells, αTC1.6 cells",

author = "Tadaho Nakamura and Takeo Yoshikawa and Fumito Naganuma and Attayeb Mohsen and Tomomitsu Iida and Yamato Miura and Akira Sugawara and Kazuhiko Yanai",

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AU - Nakamura, Tadaho

AU - Yoshikawa, Takeo

AU - Naganuma, Fumito

AU - Mohsen, Attayeb

AU - Iida, Tomomitsu

AU - Miura, Yamato

AU - Sugawara, Akira

AU - Yanai, Kazuhiko

PY - 2015

Y1 - 2015

N2 - Pancreatic α-cells secrete glucagon to maintain energy homeostasis. Although histamine has an important role in energy homeostasis, the expression and function of histamine receptors in pancreatic α-cells remains unknown. We found that the histamine H3 receptor (H3R) was expressed in mouse pancreatic α-cells and αTC1.6 cells, a mouse pancreatic α-cell line. H3R inhibited glucagon secretion from αTC1.6 cells by inhibiting an increase in intracellular Ca2+ concentration. We also found that immepip, a selective H3R agonist, decreased serum glucagon concentration in rats. These results suggest that H3R modulates glucagon secretion from pancreatic α-cells.

AB - Pancreatic α-cells secrete glucagon to maintain energy homeostasis. Although histamine has an important role in energy homeostasis, the expression and function of histamine receptors in pancreatic α-cells remains unknown. We found that the histamine H3 receptor (H3R) was expressed in mouse pancreatic α-cells and αTC1.6 cells, a mouse pancreatic α-cell line. H3R inhibited glucagon secretion from αTC1.6 cells by inhibiting an increase in intracellular Ca2+ concentration. We also found that immepip, a selective H3R agonist, decreased serum glucagon concentration in rats. These results suggest that H3R modulates glucagon secretion from pancreatic α-cells.

KW - Glucagon secretion

KW - Histamine H receptor

KW - Pancreatic α-cells

KW - αTC1.6 cells

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