Role of histamine H1 receptor in pain perception: A study of the receptor gene knockout mice

Jalal Izadi Mobarakeh, Shinobu Sakurada, Sou Katsuyama, Motoharu Kutsuwa, Atsuo Kuramasu, Zheng Yan Lin, Takeshi Watanabe, Yasuhiko Hashimoto, Takehiko Watanabe, Kazuhiko Yanai

Research output: Contribution to journalArticlepeer-review

110 Citations (Scopus)


To study the participation of histamine H1 receptors in pain perception, histamine H1 receptor knockout mice were examined for pain threshold by means of three different kinds of nociceptive tasks. These included assays for thermal nociception (hot-plate, tail-flick, paw-withdrawal), mechanical nociception (tail-pressure), and chemical nociception (abdominal constriction, formalin test, capsaicin test) which evoked pain by the activation in nociceptive Aδ and C fibers. The mutant mice lacking histamine H1 receptors showed significantly fewer nociceptive responses to the hot-plate, tail-flick, tail-pressure, paw-withdrawal, formalin, capsaicin, and abdominal constriction tests. Sensitivity to noxious stimuli in histamine H1 receptor knockout mice significantly decreased when compared to wild-type mice. This data indicates that histamine plays an important role in both somatic and visceral pain perceptions through histamine H1 receptors. The difference in the effect of histamine H1 receptors antagonist, the active (D-) and inactive (L-) isomers of chlorpheniramine on ICR mice further substantiates the evidence of the role of histamine H1 receptors on pain threshold. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)81-89
Number of pages9
JournalEuropean Journal of Pharmacology
Issue number1-2
Publication statusPublished - 2000 Mar 10


  • Gene targeting
  • Histamine
  • Histamine H receptor
  • Pain perception
  • Somatic pain
  • Visceral pain

ASJC Scopus subject areas

  • Pharmacology


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