TY - JOUR
T1 - Role of histamine H1 receptor in pain perception
T2 - A study of the receptor gene knockout mice
AU - Mobarakeh, Jalal Izadi
AU - Sakurada, Shinobu
AU - Katsuyama, Sou
AU - Kutsuwa, Motoharu
AU - Kuramasu, Atsuo
AU - Lin, Zheng Yan
AU - Watanabe, Takeshi
AU - Hashimoto, Yasuhiko
AU - Watanabe, Takehiko
AU - Yanai, Kazuhiko
N1 - Funding Information:
This work was supported by grants-in-aid from the Ministry of Education, Science and Culture and from the Ministry of Health. We thank Dr. E. Sakurai (Tohoku University School of Medicine) and Prof. K. Kisara (Tohoku Pharmaceutical University) for their suggestions.
PY - 2000/3/10
Y1 - 2000/3/10
N2 - To study the participation of histamine H1 receptors in pain perception, histamine H1 receptor knockout mice were examined for pain threshold by means of three different kinds of nociceptive tasks. These included assays for thermal nociception (hot-plate, tail-flick, paw-withdrawal), mechanical nociception (tail-pressure), and chemical nociception (abdominal constriction, formalin test, capsaicin test) which evoked pain by the activation in nociceptive Aδ and C fibers. The mutant mice lacking histamine H1 receptors showed significantly fewer nociceptive responses to the hot-plate, tail-flick, tail-pressure, paw-withdrawal, formalin, capsaicin, and abdominal constriction tests. Sensitivity to noxious stimuli in histamine H1 receptor knockout mice significantly decreased when compared to wild-type mice. This data indicates that histamine plays an important role in both somatic and visceral pain perceptions through histamine H1 receptors. The difference in the effect of histamine H1 receptors antagonist, the active (D-) and inactive (L-) isomers of chlorpheniramine on ICR mice further substantiates the evidence of the role of histamine H1 receptors on pain threshold. Copyright (C) 2000 Elsevier Science B.V.
AB - To study the participation of histamine H1 receptors in pain perception, histamine H1 receptor knockout mice were examined for pain threshold by means of three different kinds of nociceptive tasks. These included assays for thermal nociception (hot-plate, tail-flick, paw-withdrawal), mechanical nociception (tail-pressure), and chemical nociception (abdominal constriction, formalin test, capsaicin test) which evoked pain by the activation in nociceptive Aδ and C fibers. The mutant mice lacking histamine H1 receptors showed significantly fewer nociceptive responses to the hot-plate, tail-flick, tail-pressure, paw-withdrawal, formalin, capsaicin, and abdominal constriction tests. Sensitivity to noxious stimuli in histamine H1 receptor knockout mice significantly decreased when compared to wild-type mice. This data indicates that histamine plays an important role in both somatic and visceral pain perceptions through histamine H1 receptors. The difference in the effect of histamine H1 receptors antagonist, the active (D-) and inactive (L-) isomers of chlorpheniramine on ICR mice further substantiates the evidence of the role of histamine H1 receptors on pain threshold. Copyright (C) 2000 Elsevier Science B.V.
KW - Gene targeting
KW - Histamine
KW - Histamine H receptor
KW - Pain perception
KW - Somatic pain
KW - Visceral pain
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U2 - 10.1016/S0014-2999(00)00060-1
DO - 10.1016/S0014-2999(00)00060-1
M3 - Article
C2 - 10720638
AN - SCOPUS:0034629057
VL - 391
SP - 81
EP - 89
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1-2
ER -