Rôle de l'histamine et des récepteurs histaminiques dans la pathogenèse du Paludisme

Translated title of the contribution: Role of histamine and histamine receptors in the pathogenesis of Malaria

Walid Beghdadi, Adeline Porcherie, Bradley S. Schneider, David Dubayle, Roger Peronet, Michel Huerre, Takeshi Watanabe, Hiroshi Ohtsu, Jacques Louis, Salah Mécheri

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

A hallmark of the host response to Plasmodium parasite is an inflammatory reaction characterized by elevated histaminemia levels. Since histamine, which acts through four different receptors and which synthesis is under the control of the histidine decarboxylase (HDC), is endowed with pro-inflammatory and immunosuppressive activities, we hypothesized that this vaso-active amine may participe to malaria pathogenesis. Combining genetic and pharmacologic approaches by using H1R-/-, H2R-/-, H3R-/-, HDC-/- mice and H1R, H2R-, and H3Rantagonists, respectively, we found that cerebral malaria- associated pathogenetic processes such as blood brain barrier disruption, and T lymphocyte sequestration to cerebral vascular endothelium in mice were associated with histamine production. The identification of this novel inflammatory pathway and its implication in Plasmodium infection may lead to novel strategies to manipulate the anti-Plasmodium immune response and may provide new therapeutic tools to alleviate malaria disease.

Translated title of the contributionRole of histamine and histamine receptors in the pathogenesis of Malaria
Original languageFrench
Pages (from-to)377-381
Number of pages5
JournalMedecine/Sciences
Volume25
Issue number4
DOIs
Publication statusPublished - 2009 Apr 1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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