Role of functional brain imaging in the evaluation of vascular dementia

Etsuro Mori, Kazunari Ishii, Mamoru Hashimoto, Toru Imamura, Nobutsugu Hirono, Hajime Kitagaki

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)


There are various types of underlying damage to tissue and vessels in vascular dementia, including (1) single or multiple infarcts that involve association and limbic cortices, (2) small subcortical infarcts disrupting cortico-subcortical circuits, and (3) white matter lesions. The clinical picture of vascular dementia varies, and the role of functional brain imaging of cerebral blood flow and metabolism would be expected to be different among subtypes of vascular dementia. The role and value of functional brain imaging is limited for cortical infarcts; it is very valuable in assessing the impact on cortical function for small subcortical infarcts; and it is probably useful for evaluating white matter lesions, but this needs to be determined in further studies. At least in research of vascular dementia, functional brain imaging criteria should be included for proper patient selection. Careful studies using functional imaging tools in a well-characterized patient population will be needed.

Original languageEnglish
JournalAlzheimer Disease and Associated Disorders
Issue numberSUPPL. 3
Publication statusPublished - 1999 Dec 1


  • Alzheimer disease
  • Cerebral infarction
  • Functional neuroimaging
  • Positron emission tomography
  • Single photon emission computed tomography
  • Vascular dementia

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Neuroscience(all)


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