Role of FABP7 in tumor cell signaling

Yoshiteru Kagawa, Banlanjo A. Umaru, Islam Ariful, Subrata Kumar Shil, Hirofumi Miyazaki, Yui Yamamoto, Masaki Ogata, Yuji Owada

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

Lipids are major molecules for the function of organisms and are involved in the pathophysiology of various diseases. Fatty acids (FAs) signaling and their metabolism are some of the most important pathways in tumor development, as lipids serve as energetic sources during carcinogenesis. Fatty acid binding proteins (FABPs) facilitate FAs transport to different cell organelles, modulating their metabolism along with mediating other physiological activities. FABP7, brain-typed FABP, is thought to be an important molecule for cell proliferation in healthy as well as diseased organisms. Several studies on human tumors and tumor-derived cell lines put FABP7 in the center of tumorigenesis, and its high expression level has been reported to correlate with poor prognosis in different tumor types. Several types of FABP7-expressing tumors have shown an up-regulation of cell signaling activity, but molecular mechanisms of FABP7 involvement in tumorigenesis still remain elusive. In this review, we focus on the expression and function of FABP7 in different tumors, and possible mechanisms of FABP7 in tumor proliferation and migration.

Original languageEnglish
Pages (from-to)206-218
Number of pages13
JournalAdvances in Biological Regulation
Volume71
DOIs
Publication statusPublished - 2019 Jan

Keywords

  • Fatty acid binding protein 7 (FABP7)
  • Fatty acids uptake
  • Lipid raft
  • Lipid storage
  • Migration
  • PPAR interaction
  • Proliferation
  • Tumor

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Cancer Research

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