Abstract
The ETS family of transcription factors is defined by a conserved DNA-binding ETS domain that forms a winged helix-turn-helix structural motif. This family of transcription factors is involved in a diverse array of biological functions including cellular growth and differentiation, as well as organ development. Among the members of this family, ETS-1, ERG, Fli-1, TEL, and NERF-2 are expressed in endothelial cells and their progenitors. This review will summarize the role of ETS family transcription factors in vascular development and angiogenesis.
Original language | English |
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Pages (from-to) | 19-24 |
Number of pages | 6 |
Journal | Cell structure and function |
Volume | 26 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2001 |
Keywords
- Angiogenesis
- ETS
- Transcription factor
- Vasculogenesis
ASJC Scopus subject areas
- Physiology
- Molecular Biology
- Cell Biology