Role of ETS family transcription factors in vascular development and angiogenesis

Research output: Contribution to journalReview articlepeer-review

105 Citations (Scopus)

Abstract

The ETS family of transcription factors is defined by a conserved DNA-binding ETS domain that forms a winged helix-turn-helix structural motif. This family of transcription factors is involved in a diverse array of biological functions including cellular growth and differentiation, as well as organ development. Among the members of this family, ETS-1, ERG, Fli-1, TEL, and NERF-2 are expressed in endothelial cells and their progenitors. This review will summarize the role of ETS family transcription factors in vascular development and angiogenesis.

Original languageEnglish
Pages (from-to)19-24
Number of pages6
JournalCell structure and function
Volume26
Issue number1
DOIs
Publication statusPublished - 2001

Keywords

  • Angiogenesis
  • ETS
  • Transcription factor
  • Vasculogenesis

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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