Role of cholinergic receptors in adrenal catecholamine secretion in spontaneously hypertensive rats

Takahiro Nagayama, Takayuki Matsumoto, Makoto Yoshida, Mizue Suzuki-Kusaba, Hiroaki Hisa, Tomohiko Kimura, Susumu Satoh

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

We investigated the role of nicotinic and muscarinic receptors in secretion of catecholamines induced by transmural electrical stimulation (ES) from isolated perfused adrenal glands of spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto (WKY) rats. ES (1-10 Hz) produced frequency-dependent increases in epinephrine (Epi) and norepinephrine (NE) output as measured in perfusate. The ES-induced increases in NE output, but not Epi output, were significantly greater in adrenal glands of SHRs than in those of WKY rats. Hexamethonium (10-100 μM) markedly inhibited the ES- induced increases in Epi and NE output from adrenal glands of SHRs and WKY rats. Atropine (0.3-3 μM) inhibited the ES-induced increases in Epi and NE output from adrenal glands of SHRs, but not from those of WKY rats. These results suggest that endogenous acetylcholine-induced secretion of adrenal catecholamines is predominantly mediated by nicotinic receptors in SHRs and WKY rats and that the contribution of muscarinic receptors may be different between these two strains.

Original languageEnglish
Pages (from-to)R1057-R1062
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume277
Issue number4 46-4
DOIs
Publication statusPublished - 1999 Oct

Keywords

  • Adrenal gland
  • Atropine
  • Hexamethonium
  • Muscarinic receptors
  • Nicotinic receptors

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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