Role of acetylcholine receptor subunits in gating of the channel

Bert Sakmann; Christoph Methfessel; Masayoshi Mishina; Tomoyuki Takahashi; Toshiyuki Takai; Masaaki Kurasaki; Kazuhiko Fukuda; Shosaku Numa

doi:10.1038/318538a0

Role of acetylcholine receptor subunits in gating of the channel

Bert Sakmann, Christoph Methfessel, Masayoshi Mishina, Tomoyuki Takahashi, Toshiyuki Takai, Masaaki Kurasaki, Kazuhiko Fukuda, Shosaku Numa

Research output: Contribution to journal › Article › peer-review

168 Citations (Scopus)

Abstract

The Torpedo and calf acetylcholine receptors and hybrids composed of subunits from the two species have been produced in Xenopus oocytes by the use of the cloned complementary DNAs. Single-channel current measurements indicate that these receptors form channels of similar conductance but with different gating behaviour.

Original language	English
Pages (from-to)	538-543
Number of pages	6
Journal	Nature
Volume	318
Issue number	6046
DOIs	https://doi.org/10.1038/318538a0
Publication status	Published - 1985 Dec 1
Externally published	Yes

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title = "Role of acetylcholine receptor subunits in gating of the channel",

abstract = "The Torpedo and calf acetylcholine receptors and hybrids composed of subunits from the two species have been produced in Xenopus oocytes by the use of the cloned complementary DNAs. Single-channel current measurements indicate that these receptors form channels of similar conductance but with different gating behaviour.",

author = "Bert Sakmann and Christoph Methfessel and Masayoshi Mishina and Tomoyuki Takahashi and Toshiyuki Takai and Masaaki Kurasaki and Kazuhiko Fukuda and Shosaku Numa",

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AU - Sakmann, Bert

AU - Methfessel, Christoph

AU - Mishina, Masayoshi

AU - Takahashi, Tomoyuki

AU - Takai, Toshiyuki

AU - Kurasaki, Masaaki

AU - Fukuda, Kazuhiko

AU - Numa, Shosaku

PY - 1985/12/1

Y1 - 1985/12/1

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Role of acetylcholine receptor subunits in gating of the channel

Abstract

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