Role of a transcription factor Pax6 in the developing vertebrate olfactory system

Tadashi Nomura; Hasumi Haba; Noriko Osumi

doi:10.1111/j.1440-169X.2007.00965.x

Role of a transcription factor Pax6 in the developing vertebrate olfactory system

Tadashi Nomura, Hasumi Haba, Noriko Osumi

MED - United Centers for Advanced Research and Translational Medicine (ART)

Research output: Contribution to journal › Review article › peer-review

38 Citations (Scopus)

Abstract

The olfactory system is responsible for capturing and processing odorant information, which significantly influences a variety of behaviors in animals. The vertebrate olfactory system consists of several neuronal components including the olfactory epithelium, olfactory bulb and olfactory cortex, which originate from distinct embryonic tissues. The transcription factor Pax6 is strongly expressed in the embryonic and postnatal olfactory systems, and regulates neuronal specification, migration and differentiation. Here we review classical and recent studies focusing on the role of Pax6 in the developing olfactory system, and highlight the cellular and molecular mechanisms underlying the highly coordinated developmental processes of the vertebrate olfactory system.

Original language	English
Pages (from-to)	683-690
Number of pages	8
Journal	Development Growth and Differentiation
Volume	49
Issue number	9
DOIs	https://doi.org/10.1111/j.1440-169X.2007.00965.x
Publication status	Published - 2007 Dec

Keywords

Neurogenesis
Neuronal migration
Olfactory system
Pax6
fgf

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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AB - The olfactory system is responsible for capturing and processing odorant information, which significantly influences a variety of behaviors in animals. The vertebrate olfactory system consists of several neuronal components including the olfactory epithelium, olfactory bulb and olfactory cortex, which originate from distinct embryonic tissues. The transcription factor Pax6 is strongly expressed in the embryonic and postnatal olfactory systems, and regulates neuronal specification, migration and differentiation. Here we review classical and recent studies focusing on the role of Pax6 in the developing olfactory system, and highlight the cellular and molecular mechanisms underlying the highly coordinated developmental processes of the vertebrate olfactory system.

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