Role of β-chemokines in mast cell activation and type I hypersensitivity reactions in the conjunctiva: In vivo and in vitro studies

Frederick Beer, Chuan Hui Kuo, Kei Morohoshi, James Goodliffe, Peter Munro, Cho Cho Aye, Maria Dawson, Ricardo M. Richardson, Limei H. Jones, Yoshifumi Ikeda, Takao Nakamura, Masako Toda, Tom Flynn, Masaharu Ohbayashi, Dai Miyazaki, Santa Jeremy Ono

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

Chemokines have a clearly defined role in mobilizing the recruitment of leukocytes to both healthy and inflamed tissues. This review details work from our and other laboratories, indicating that β-chemokines may play important roles (i) in driving the terminal differentiation of mast cell precursors in mucosal tissues and (ii) in providing priming or costimulatory signals required for mast cell activation, leading to an antigen-driven inflammatory response. These data stem from in vivo, ex vivo, and in vitro studies. Data are also presented that suggest that FcεRI:chemokine receptor cross talk may involve spatiotemporal dynamics that may control the strength and nature of the complex activating signals controlling mast cell effector function.

Original languageEnglish
Pages (from-to)96-104
Number of pages9
JournalImmunological Reviews
Volume217
Issue number1
DOIs
Publication statusPublished - 2007 Jun 1
Externally publishedYes

Keywords

  • Chemokines
  • Mast cells
  • Signal transduction

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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