Abstract
How to construct a reliable deoxyribonucleic acid (DNA) circuit is one of the most important issues in the field of molecular programming and computing. Such a circuit frequently suffers from various kinds of unintended binding reactions on account of a lower specificity of the molecular interaction emerging from base complementarity between DNA strands, which results in low reliability of the molecular circuit. In this study, we propose a method to quantitatively evaluate the robustness of a DNA circuit created by DNA strand displacement reactions. The highlight of our method is representing the circuit system contaminated by unintended reactions by a standard form of a disturbed nonlinear system and evaluating the robustness with the L2 gain by solving the Hamilton–Jacobi inequality.
Original language | English |
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Pages (from-to) | 32-37 |
Number of pages | 6 |
Journal | IFAC-PapersOnLine |
Volume | 51 |
Issue number | 33 |
DOIs | |
Publication status | Published - 2018 Jan 1 |
Keywords
- Complex systems
- Differential equations, Robustness
- Nonlinear circuits
- Uncertainty
ASJC Scopus subject areas
- Control and Systems Engineering