RNA recognition and recognition control of alpha-peptide ribonucleic acids containing arginine residue by external factors.

Takehiko Wada, Yoshiki Maeda, Nobuya Sawa, Hirofumi Sato, Shiroh Futaki, Yoshihisa Inoue

Research output: Contribution to journalArticlepeer-review

Abstract

A novel nucleic acid model using alpha-peptide ribonucleic acid (alpha-PRNA) possessing alternative alpha-PRNA/lysine and alpha-PRNA/arginine sequences, where the lysine or arginine residue are expected to stabilize the complex not only by the conventional hydrogen-bonding interactions between the complementary nucleobase pairs but also through the electrostatic interactions between basic amino acid side-chain groups and DNA's phosphate anions on the backbone. These alpha-PRNAs form stable sequence-specific complex with the complementary DNA.

Original languageEnglish
Pages (from-to)75-76
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number50
DOIs
Publication statusPublished - 2006
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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