RNA oxidation in Alzheimer and Parkinson diseases

Akihiko Nunomura, George Perry, Jing Zhang, Thomas J. Montine, Atsushi Takeda, Shigeru Chiba, Mark A. Smith

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

In Alzheimer and Parkinson diseases, oxidative alterations, affecting lipids, proteins, and DNA, have been described. Using an in situ approach to identify 8-hydroxyguanosine, an oxidized nucleoside, we recently identified RNA as a major target of oxidation in Alzheimer and Parkinson diseases as well as Down syndrome, where premature Alzheimer-like neuropathology is invariably found. RNA oxidation is localized to the neuronal populations potentially affected in these diseases. Together with the known mitochondrial dysfunction in Alzheimer and Parkinson diseases, the cytoplasmic predominance of neuronal 8-hydroxyguanosine supports mitochondria as the most likely source of reactive oxygen responsible for RNA oxidation. The consequence of oxidatively damaged RNA is not fully understood; however, the potential of oxidized RNA to cause errors in translation indicates a metabolic abnormality in neurodegenerative diseases.

Original languageEnglish
Pages (from-to)227-230
Number of pages4
JournalJournal of Anti-Aging Medicine
Volume2
Issue number3
DOIs
Publication statusPublished - 1999 Jan 1

ASJC Scopus subject areas

  • Ageing

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