Risk of neurodevelopmental disease by paternal aging: A possible influence of epigenetic alteration in sperm

Ryuichi Kimura, Kaichi Yoshizaki, Noriko Osumi

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

Sincethe theory of DOHaD has been thrown in the spotlight, most attention has focused on environmental effects of the uterus on developing embryos/fetuses. However, the ontogenesis traces back to gametogenesis. Compared to oogenesis, spermatogenesis goes through far more cell divisions and is therefore more prone to genetic variation and epigenetic alterations. This article will mainly discuss recent findings about the effects of the advanced paternal age on the next generation, in relation to the onset of psychiatric disorders such as autism spectrum disorder. We would like to advocate for further exploration on the DOHaD theory in a wider view.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages75-81
Number of pages7
DOIs
Publication statusPublished - 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1012
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Neurodevelopmental disorder
  • Paternal aging
  • Sperm epigenetics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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