Risk of breast cancer in Japanese women with benign breast disease

Yuko Minami, Noriaki Ohuchi, Yoshinori Taeda, Akira Takano, Akira Fukao, Susumu Satomi, Shigeru Hisamichi

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


To investigate the risk of breast cancer development in women with benign breast disease (BBD), 387 screen-detected BBD women and 1489 normal women, taken from participants in the breast cancer screening program during 1978-1986, were followed through 1991. While 2811 person-years in the BBD group and 11,018 person-gears in the normal group were accumulated, 5 women in the BBD group and 6 women in the normal group developed breast cancer. Using the Mantel-Haenszel method, relative risks (RR) were estimated for all women with BBD and women in some BBD types. Significantly elevated risk of breast cancer was observed in all women with BBD (RR = 3.26, 95% confidence interval (CI) 1.08-9.83). Women with proliferative BBD were at high risk of breast cancer (RR = 8.48, 95% CI 2.99-24.10), but no increased risk was observed for women with non-proliferative BBD (RR = 0.93, 95% CI 0.11-7.66). These results are consistent with those in high-risk countries for breast cancer. In the management of women with BBD, histopathological diagnosis of the breast lesion is essential and women with proliferative BBD should be followed up carefully.

Original languageEnglish
Pages (from-to)600-606
Number of pages7
JournalJapanese Journal of Cancer Research
Issue number6
Publication statusPublished - 1999 Jun
Externally publishedYes


  • Benign breast disease
  • Breast cancer risk
  • Cancer registry
  • Retrospective cohort study
  • Screening

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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