Risk factors in past histories and familial episodes related to development of testicular germ cell tumor

Satoru Kanto, Masayoshi Hiramatsu, Kenichi Suzuki, Shigeto Ishidoya, Hideo Saito, Shigeyuki Yamada, Makoto Satoh, Seiichi Saito, Atsushi Fukuzaki, Yoichi Arai

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Background: A retrospective study was conducted to examine the host factors of 240 testicular germ cell tumor patients. This study was performed to address a new theory proposed by Skakkebaek called testicular dysgenesis syndrome which claims that cryptorchism, hypospadias, poor semen quality and testicular germ cell tumors are symptoms of an underlying testicular dysgenesis in uterus. Methods: The past health histories and familial episodes of 240 testicular germ cell tumor patients were examined. The past health histories included cryptorchism, hypospadias, infertility, atrophic testis and inguinal hernia. Results: Of the 240 patients, 13 (5.4%) had a history of cryptorchism or orchidopexy. Two (0.8%) showed existence of hypospadias or had experienced urethroplasty. Among 129 married couples, 104 (80.6%) couples were fertile. Three (1.3%) patients developed testicular tumors after they were diagnosed as infertile or came to the hospital with the complaints of infertility. Four (1.7%) had contralateral atrophic testis. 19 (7.9%) had experienced inguinal herniorrhaphy before age 15. Three (1.3%) had testicular germ cell tumor patients among their family or relatives. Conclusions: The testicular germ cell tumor patients showed a considerable incidence of complications such as cryptorchism, hypospadias and incomplete closure of processus vaginalis. Cryptorchism, perinatal factors and familial factors could be risks for developing testicular germ cell tumors.

Original languageEnglish
Pages (from-to)640-646
Number of pages7
JournalInternational Journal of Urology
Issue number8
Publication statusPublished - 2004 Aug


  • Cryptorchism
  • Familial
  • Hypospadias
  • Infertility
  • Inguinal hernia
  • Testicular germ cell tumor

ASJC Scopus subject areas

  • Urology


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