Risk factors for severe gastrointestinal toxicity in patients receiving palliative radiotherapy for metastatic bone tumors: Association with the use of molecular-targeted agents

Yuji Murakami, Masahiro Kenjo, Kazuki Ishikawa, Toru Sakayauchi, Satoshi Itasaka, Yoshiharu Negoro, Keiichi Jingu, Yasumasa Nishimura, Yasushi Nagata, Kazuhiko Ogawa

Research output: Contribution to journalArticlepeer-review

Abstract

This study aimed to investigatewhether the use of molecular-targeted agents could affect gastrointestinal (GI) toxicity in palliative radiotherapy (RT) formetastatic bone tumors in the abdominopelvic region. We collected data of patients who received palliative RT for bone metastases in the abdominopelvic region between 2013 and 2014 from six institutions. Data of 395 patients were collected and184 patients received molecularly targeted therapy, of whom 80 received vascular endothelial growth factor (VEGF)-targeted agents. For 556 lesions, 410 sessions of irradiation were undergone. GI toxicity of ≥G3 was observed in 3.8% of patients. The incidence rates of ≥G3 GI toxicity in patients without targeted agents use, in those using VEGF-targeted agents and in those using non-VEGF-targeted agents were 3.8, 7.5 and 1.0%, respectively. Regarding risk factors of the occurrence of ≥G3 GI toxicity, univariate analysis in all patients showed that a history of abdominopelvic surgerywas a significant risk factor (P=0.01), and the use ofVEGFtargeted agents showed a trend of high incidence (P=0.06). In patients using VEGF-targeted agents, both univariate andmultivariate analysis showed that combined anticoagulantuse (P=0.03 and 0.01) and agent use between 1 week before and after RT (P = 0.046 and 0.03) were significant risk factors. In conclusion, the history of abdominopelvic surgery was associated with ≥G3 GI toxicity and the use of VEGF-targeted agents showed a trend for high incidence. When using VEGF-targeted agents, caution should be exercised in the combined use of anticoagulants and in the agent use between 1 week before and after RT.

Original languageEnglish
Pages (from-to)629-634
Number of pages6
JournalJournal of radiation research
Volume61
Issue number4
DOIs
Publication statusPublished - 2020 Jul 1

Keywords

  • Bone metastasis
  • Gastrointestinal toxicity
  • Molecularly targeted therapy
  • Palliative radiotherapy
  • Vascular endothelial growth factor-targeted agent

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis

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