TY - JOUR
T1 - Risk factors for postoperative local recurrence of tongue carcinoma
AU - Kurokawa, Hideo
AU - Zhang, Min
AU - Yamashita, Yoshihiro
AU - Matsumoto, Shinobu
AU - Takano, Hiroshi
AU - Funaki, Katsuyuki
AU - Tomoyose, Taiki
AU - Shibuya, Tomoaki
AU - Fukuyama, Hiroshi
AU - Takahashi, Tetsu
PY - 2004/1/1
Y1 - 2004/1/1
N2 - Objective: To identify the clinicopathologic factors associated with postoperative local recurrence in patients with carcinoma of the tongue. Patients and Methods: Clinicopathologic factors were reviewed in 50 patients seen between 1985 and 1996 with previously untreated stage I or stage II squamous cell carcinoma of the tongue. All of the patients underwent partial glossectomy without elective neck dissection. Postoperative local recurrence occurred in 13 patients (26.0%) within 8 to 16 months of surgery for the primary tumour. Clinicopathologic factors were analysed using logistic regression to determine factors predicting postoperative local recurrence of tongue carcinoma. Results: Postoperative local recurrence was positively associated with tumour size (≥30 mm), tumour thickness (>4 mm), and epithelial dysplasia score within 3 mm of the surgical margin (≥4 points). In a multivariate logistic regression analysis, patients with epithelial dysplasia score of ≥4 points within 3 mm of the surgical margin had a predictive value for postoperative local recurrence (odds ratio, 36.6; p < 0.0001). Conclusions: Patients with an epithelial dysplasia score of ≥4 points within 3 mm of the surgical margin have a higher risk of postoperative local recurrence. It is recommended that this diagnostic factor be used in deciding about re-excision or additional therapy.
AB - Objective: To identify the clinicopathologic factors associated with postoperative local recurrence in patients with carcinoma of the tongue. Patients and Methods: Clinicopathologic factors were reviewed in 50 patients seen between 1985 and 1996 with previously untreated stage I or stage II squamous cell carcinoma of the tongue. All of the patients underwent partial glossectomy without elective neck dissection. Postoperative local recurrence occurred in 13 patients (26.0%) within 8 to 16 months of surgery for the primary tumour. Clinicopathologic factors were analysed using logistic regression to determine factors predicting postoperative local recurrence of tongue carcinoma. Results: Postoperative local recurrence was positively associated with tumour size (≥30 mm), tumour thickness (>4 mm), and epithelial dysplasia score within 3 mm of the surgical margin (≥4 points). In a multivariate logistic regression analysis, patients with epithelial dysplasia score of ≥4 points within 3 mm of the surgical margin had a predictive value for postoperative local recurrence (odds ratio, 36.6; p < 0.0001). Conclusions: Patients with an epithelial dysplasia score of ≥4 points within 3 mm of the surgical margin have a higher risk of postoperative local recurrence. It is recommended that this diagnostic factor be used in deciding about re-excision or additional therapy.
KW - Epithelial dysplasia
KW - Local
KW - Neoplasm recurrences
KW - Risk factor
KW - Tongue cancer
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U2 - 10.1016/S0915-6992(04)80015-3
DO - 10.1016/S0915-6992(04)80015-3
M3 - Article
AN - SCOPUS:7944224297
VL - 16
SP - 91
EP - 96
JO - Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
JF - Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
SN - 2212-5558
IS - 2
ER -