Risk factors for human infection with avian influenza A H5N1, Vietnam, 2004

Ngoc Dinh Pham, Thuy Long Hoang, Nguyen Thi Kim Tien, Tran Hien Nguyen, Le Thi Quynh Mai, Hong Phong Le, Van Tuan Le, Van Tan Hoang, Binh Nguyen Nguyen, Van Tu Phan, Nguyen Thi Minh Phuong, Huy Anh Bach, Philippe Barboza, Niranjan Bhat, Aaron Curns, Cong Doan Nguyen, Jackie Katz, Keiji Fukuda, Amy Funk, Taronna MainesMark Simmerman, Terry Tumpey, Timothy Uyeki, Arnold Bosman, Mirna Du Ry Van Beest Holle, Sofia Boqvist, Rick Brown, Futoshi Hasabe, Pascale Brudon, Philippe Calain, Robert Dietz, Rodger Doran, Tom Grein, Peter Horby, Hitoshi Oshitani, Valerie Delpech, Patrice Gautier, Shigeyuki Itamura, Takehiko Saito, Donna Mak, Noel Miranda, Reiko Saito, Joel Francart

Research output: Contribution to journalArticle

165 Citations (Scopus)

Abstract

To evaluate risk factors for human infection with influenza A subtype H5N1, we performed a matched casecontrol study in Vietnam. We enrolled 28 case-patients who had laboratory-confirmed H5N1 infection during 2004 and 106 age-, sex-, and location-matched control-respondents. Data were analyzed by matched-pair analysis and multivariate conditional logistic regression. Factors that were independently associated with H5N1 infection were preparing sick or dead poultry for consumption ≤7 days before illness onset (matched odds ratio [OR] 8.99, 95% confidence interval [CI] 0.98-81.99, p = 0.05), having sick or dead poultry in the household ≤7 days before illness onset (matched OR 4.94, 95% CI 1.21-20.20, p = 0.03), and lack of an indoor water source (matched OR 6.46, 95% CI 1.20-34.81, p = 0.03). Factors not significantly associated with infection were raising healthy poultry, preparing healthy poultry for consumption, and exposure to persons with an acute respiratory illness.

Original languageEnglish
Pages (from-to)1841-1847
Number of pages7
JournalEmerging Infectious Diseases
Volume12
Issue number12
Publication statusPublished - 2006 Dec 1
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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    Pham, N. D., Hoang, T. L., Tien, N. T. K., Nguyen, T. H., Mai, L. T. Q., Le, H. P., Le, V. T., Hoang, V. T., Nguyen, B. N., Phan, V. T., Phuong, N. T. M., Bach, H. A., Barboza, P., Bhat, N., Curns, A., Nguyen, C. D., Katz, J., Fukuda, K., Funk, A., ... Francart, J. (2006). Risk factors for human infection with avian influenza A H5N1, Vietnam, 2004. Emerging Infectious Diseases, 12(12), 1841-1847.