Risk factors for adverse reactions from contrast agents for computed tomography

Daiki Kobayashi, Osamu Takahashi, Takuya Ueda, Gautam A. Deshpande, Hiroko Arioka, Tsuguya Fukui

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Background: Symptoms of an adverse reaction to contrast agents for computed tomography are diverse ranging, and sometimes serious. The goal of this study is to create a scoring rule to predict adverse reactions to contrast agents used in computed tomography. Methods: This was a retrospective cohort study of all adult patients undergoing contrast enhanced CT scan for 7 years. The subjects were randomly divided into either a derivation or validation group. Baseline data and clinically relevant factors were collected from the electronic chart. Primary outcome was any acute adverse reactions to contrast media, observed for during 24 hours after administration. All potential candidate predictors were included in a forward stepwise logistic regression model. Prediction scores were assigned based on β coefficient. A receiver operating characteristic (ROC) curve was drawn, and the area under the curve (AUC) and incidence of acute adverse reactions at each point were obtained. The same process was performed in the validation group. Results: 36,472 patients underwent enhanced CT imaging: 20,000 patients in the derivation group and 16,472 in the validation group. A total of 409 (2.0%, 95% CI:1.9-2.3) and 347 (2.1%, 95% CI:1.9-2.3) acute adverse reactions were seen in the derivation and validation groups. Logistic regression analysis revealed that prior adverse reaction to contrast agents, urticaria, an allergic history to drugs other than contrast agents, contrast agent concentration >70%, age <50 years, and total contrast agent dose >65 g were significant predictors of an acute adverse reaction. AUC was 0.70 (95% CI:0.67-0.73) and 0.67 (95% CI:0.64-0.70) in the derivation and validation groups. Conclusions: We suggest a prediction model consisting of six predictors for acute adverse reactions to contrast agents used in CT.

Original languageEnglish
Article number18
JournalBMC Medical Informatics and Decision Making
Volume13
Issue number1
DOIs
Publication statusPublished - 2013
Externally publishedYes

ASJC Scopus subject areas

  • Health Policy
  • Health Informatics

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