Risk assessment for acute kidney injury after allogeneic hematopoietic stem cell transplantation based on acute kidney injury network criteria

Jinichi Mori, Kazuteru Ohashi, Takuhiro Yamaguchi, Minoru Ando, Yuka Hirashima, Takeshi Kobayashi, Kazuhiko Kakihana, Hisashi Sakamaki

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

Objective This is a retrospective study for risk assessment of acute kidney injury after allogeneic hematopoietic stem cell transplantation (allo HSCT) based on the Acute Kidney Injury Network (AKIN) criteria. Methods Two hundred and eighty-nine consecutive patients who received allo HSCT were studied retrospectively to identify the risk factors for AKI according to the AKIN criteria. The incidence of AKI based on AKIN staging and overall survival (OS) was evaluated using Cox proportional hazard regression models treating each AKIN stage as a time-dependent covariate. Patients We identified a total of 180 patients who developed AKI within 100 days after allo HSCT; AKI was classified as stage 1 in 88 patients (30.5%), stage 2 in 46 patients (15.9%) and stage 3 in 46 patients (15.9%). Results Patients who developed stage 3 AKI had a significantly worse survival compared to those who developed no AKI or lower stage AKI (HR: 7.6, 95%CI: 4.8-12.1; p<0.001). Multivariate analysis for risks for developing AKI revealed an episode of sepsis or sinusoidal obstruction syndrome (SOS) and the use of liposomal amphotericin as a major cause of the severe stage of AKI. Conclusion On the basis of our analysis, sepsis, hemorrhagic cystitis, and acute GVHD were associated with severe AKI, and SOS was associated any stage of AKI.

Original languageEnglish
Pages (from-to)2105-2110
Number of pages6
JournalInternal Medicine
Volume51
Issue number16
DOIs
Publication statusPublished - 2012

Keywords

  • AKIN criteria
  • Hematopoietic stem cell transplantation
  • Renal function
  • Risk assessment

ASJC Scopus subject areas

  • Internal Medicine

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