Rigidity sensing explained by active matter theory

Philippe Marcq; Natsuhiko Yoshinaga; Jacques Prost

doi:10.1016/j.bpj.2011.08.023

Rigidity sensing explained by active matter theory

Philippe Marcq, Natsuhiko Yoshinaga, Jacques Prost

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

The magnitude of traction forces exerted by living animal cells on their environment is a monotonically increasing and approximately sigmoidal function of the stiffness of the external medium. We rationalize this observation using active matter theory, and propose that adaptation to substrate rigidity results from an interplay between passive elasticity and active contractility.

Original language	English
Pages (from-to)	L33-L35
Journal	Biophysical Journal
Volume	101
Issue number	6
DOIs	https://doi.org/10.1016/j.bpj.2011.08.023
Publication status	Published - 2011 Sep 21
Externally published	Yes

ASJC Scopus subject areas

Biophysics

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10.1016/j.bpj.2011.08.023

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title = "Rigidity sensing explained by active matter theory",

abstract = "The magnitude of traction forces exerted by living animal cells on their environment is a monotonically increasing and approximately sigmoidal function of the stiffness of the external medium. We rationalize this observation using active matter theory, and propose that adaptation to substrate rigidity results from an interplay between passive elasticity and active contractility.",

author = "Philippe Marcq and Natsuhiko Yoshinaga and Jacques Prost",

note = "Funding Information: This work was supported by the Japan Society for the Promotion of Science, the Ministry of Foreign and European Affairs, and the Ministry of Education and Scientific Research under the Japan-France Integrated Action Program SAKURA.",

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AU - Yoshinaga, Natsuhiko

AU - Prost, Jacques

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PY - 2011/9/21

Y1 - 2011/9/21

N2 - The magnitude of traction forces exerted by living animal cells on their environment is a monotonically increasing and approximately sigmoidal function of the stiffness of the external medium. We rationalize this observation using active matter theory, and propose that adaptation to substrate rigidity results from an interplay between passive elasticity and active contractility.

AB - The magnitude of traction forces exerted by living animal cells on their environment is a monotonically increasing and approximately sigmoidal function of the stiffness of the external medium. We rationalize this observation using active matter theory, and propose that adaptation to substrate rigidity results from an interplay between passive elasticity and active contractility.

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Rigidity sensing explained by active matter theory

Abstract

ASJC Scopus subject areas

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