Rice bran fractions improve blood pressure, lipid profile, and glucose metabolism in stroke-prone spontaneously hypertensive rats

Ardiansyah, Hitoshi Shirakawa, Takuya Koseki, Kousaku Ohinata, Katsumi Hashizume, Michio Komai

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)

Abstract

Effect of dietary supplementation of two types of rice bran fraction on blood pressure (BP), lipid profile, and glucose metabolism in stroke-prone spontaneously hypertensive rats was studied. Male 4-week-old rats were divided into one group fed the AIN-93M-based control (C) diet and two groups fed diet supplemented with 60 g/kg of Driselase and ethanol fractions (DF and EF, respectively) of rice bran. After 8 weeks feeding, the BP decreased in the DF and EF groups in comparison with the C group (p < 0.01). Plasma ACE inhibitory activity, BUN, BUN/creatinine ratio, albumin, triglyceride, and glucose levels were lower in the DF and EF groups than in the C group (p < 0.01). Plasma nitric oxide and urinary 8-hydroxy-2′-deoxyguanosine levels were lower in the DF and EF groups than in the C group (p < 0.01). Rice bran fractions appear to have a beneficial dietary component that improves hypertension, hyperlipidemia, and hyperglycemia.

Original languageEnglish
Pages (from-to)1914-1920
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume54
Issue number5
DOIs
Publication statusPublished - 2006 Mar 8

Keywords

  • 8-OHdG
  • ACE inhibitory activity
  • Blood pressure
  • Driselase fraction
  • Ethanol fraction
  • Glucose level
  • Lipid profile
  • Nitric oxide
  • Rice bran

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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