Rhodium-HMPT-catalyzed direct ortho arylation of phenols with aryl bromides

Shuichi Oi, Shun Ichiro Watanabe, Susumu Fukita, Yoshio Inoue

Research output: Contribution to journalArticlepeer-review

136 Citations (Scopus)

Abstract

Direct ortho arylation of phenols with aryl bromides catalyzed by a rhodium complex and hexamethylphosphorous triamide (HMPT) have been developed. A plausible reaction mechanism involving in situ generation of arylphosphites from phenols and HMPT, phosphorus-directed ortho metalation, and transesterification of the arylated arylphosphites with the substrate phenols is proposed.

Original languageEnglish
Pages (from-to)8665-8668
Number of pages4
JournalTetrahedron Letters
Volume44
Issue number48
DOIs
Publication statusPublished - 2003 Nov 24

Keywords

  • Aryl halide
  • Arylation
  • Phenol
  • Rhodium catalyst

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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