@article{a13353b7175c43548a8060cbfd40fbf3,
title = "Rhodium-catalyzed synthesis of organosulfur compounds involving S-S bond cleavage of disulfides and sulfur",
abstract = "Organosulfur compounds are widely used for the manufacture of drugs and materials, and their synthesis in general conventionally employs nucleophilic substitution reactions of thiolate anions formed from thiols and bases. To synthesize advanced functional organosulfur compounds, development of novel synthetic methods is an important task. We have been studying the synthesis of organosulfur compounds by transition-metal catalysis using disulfides and sulfur, which are easier to handle and less odiferous than thiols. In this article, we describe our development that rhodium complexes efficiently catalyze the cleavage of S-S bonds and transfer organothio groups to organic compounds, which provide diverse organosulfur compounds. The synthesis does not require use of bases or organometallic reagents; furthermore, it is reversible, involving chemical equilibria and interconversion reactions.",
keywords = "Catalysis, Chemical equilibrium, Organosulfur compounds, Reversible reaction, Rhodium, S-S bond cleavage, Synthesis",
author = "Mieko Arisawa and Masahiko Yamaguchi",
note = "Funding Information: Author Contributions: Writing, M.A. and M.Y. All authors have read and agreed to the published version of Author Contributions: Writing, M.A. and M.Y. All authors have read and agreed to the published version of the manuscript. the manuscript. Funding: This research was supported by the Japan Agency for Medical Research and Development (AMED), PPllaattffoorrmm PPrroojjeecctt ffoorr SSuuppppoorrttiinngg DDrruugg DDiissccoovveerryy aanndd LLiiffee SScciieennccee RReesseeaarrcchh ((GGrraanntt NNuummbbeerr JJPP1199 aamm00110011110000)),, Nagase Science and Technology Foundation, Kobayashi Foundation, and Tohoku University Center for Gender Equality Promotion (TUMUG). Conflicts of Interest: The authors declare no conflict of interest. Conflicts of Interest: The authors declare no conflict of interest. Funding Information: This research was supported by the Japan Agency for Medical Research and Development (AMED), Platform Project for Supporting Drug Discovery and Life Science Research (Grant Number JP19 am0101100), Nagase Science and Technology Foundation, Kobayashi Foundation, and Tohoku University Center for Gender Equality Promotion (TUMUG). Publisher Copyright: {\textcopyright} 2020 by the authors.",
year = "2020",
month = aug,
doi = "10.3390/molecules25163595",
language = "English",
volume = "25",
journal = "Molecules",
issn = "1420-3049",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "16",
}