Rhodium-catalyzed cross coupling of unactivated allenes and 1-alkynes

Masahiko Yamaguchi, Kenji Omata, Masahiro Hirama

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

Mixture of HRh(CO)(PPh3)3 and Et3P catalyzes cross coupling reaction of unactivated allenes and 1-alkynes. CC bond formation takes place regioselectively at 2-position of allenes giving endo-(E)-enynes in high yields and selectivities. Added PEt3 promotes the reaction and enhances the regio- and stereoselectivity.

Original languageEnglish
Pages (from-to)5689-5692
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number31
DOIs
Publication statusPublished - 1994 Aug 1

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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