Rhodium-catalyzed carbothiolation reaction of 1-alkylthio-1-alkynes

Mieko Arisawa, Yui Igarashi, Yoko Tagami, Masahiko Yamaguchi, Chizuko Kabuto

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

A rhodium complex derived from RhH(PPh3)4 and Me 2PhP catalyzed the carbothiolation reaction of 1-alkylthio-1-alkynes and 1,4-diaryl-1,3-butadiynes giving (Z)-4-alkylthio-4-aryl-3-arylethynyl-3- buten-1-ynes. Terminal alkynes such as 1-decyne and (t-butylthio)acetylene underwent the carbothiolation reaction using a RhH(PPh3) 4-dppb catalyst. The reactions proceeded via cis-addition with C-C bond formation at the less hindered acetylene carbon.

Original languageEnglish
Pages (from-to)920-922
Number of pages3
JournalTetrahedron Letters
Volume52
Issue number8
DOIs
Publication statusPublished - 2011 Feb 23

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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