Rho effecters and reorganization of actin cytoskeleton

Shuh Narumiya, Toshimasa Ishizaki, Naoki Watanabe

Research output: Contribution to journalArticlepeer-review

330 Citations (Scopus)


The small GTPase Rho regulates several actomyosin-based cellular processes such as cell adhesion, cytokinesis and contraction. The biochemical mechanisms of these actions remain unknown. Recently, several GTP-Rho binding proteins were isolated. Among them, p140mDia and p160ROCK appear to work as Rho effecters mediating its action on the cytoskeleton. p140mDia induces actin polymerization by recruiting an actin binding protein, profilin, to the site of Rho action. p160ROCK induces focal adhesions and stress fibers by activating integrin and clustering them by the use of myosin-based contractility.

Original languageEnglish
Pages (from-to)68-72
Number of pages5
JournalFEBS Letters
Issue number1
Publication statusPublished - 1997 Jun 23
Externally publishedYes


  • Actin polymerization
  • Cell adhesion
  • Contractility
  • Focal adhesion
  • Rho GTPase
  • Stress fiber

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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