Abstract
Rhinovirus infection has attracted attention because it can lead to acute exacerbations of chronic inflammatory airway diseases such as bronchial asthma and chronic bronchitis. We established a culture system and inoculated human rhinovirus to human tracheal epithelial cells, and found that infection was augmented by up-regulation of intercellular adhesion molecule-1, which is the receptor for this virus. We also found that human airway epithelial cells infected with rhinovirus were susceptible to a chemical oxidant (H2O2) released by inflammatory cells, which would contribute to acute exacerbations of inflammatory airway diseases. Finally, we found that anti-ICAM-1 antibodies or dexamethasone can inhibit the infectivity to rhinovirus by suppressing ICAM-1, and diminish susceptibility to oxidants in the cultured human tracheal epithelium.
Original language | English |
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Pages (from-to) | 121-125 |
Number of pages | 5 |
Journal | Japanese Journal of Thoracic Diseases |
Volume | 34 |
Issue number | SUPPL. |
Publication status | Published - 1996 |
Keywords
- Adhesion molecule
- Airway epithelial cell
- Cytokine
- Rhinovirus
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine