Rhinovirus infection and expression of adhesion molecules in human tracheal epithelium

T. Ohrui, M. Yamaya, K. Sekizawa, M. Terajima, N. Yamada, T. Suzuki, S. Okinaga, H. Hoshi, H. Suzuki, H. Sasaki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Rhinovirus infection has attracted attention because it can lead to acute exacerbations of chronic inflammatory airway diseases such as bronchial asthma and chronic bronchitis. We established a culture system and inoculated human rhinovirus to human tracheal epithelial cells, and found that infection was augmented by up-regulation of intercellular adhesion molecule-1, which is the receptor for this virus. We also found that human airway epithelial cells infected with rhinovirus were susceptible to a chemical oxidant (H2O2) released by inflammatory cells, which would contribute to acute exacerbations of inflammatory airway diseases. Finally, we found that anti-ICAM-1 antibodies or dexamethasone can inhibit the infectivity to rhinovirus by suppressing ICAM-1, and diminish susceptibility to oxidants in the cultured human tracheal epithelium.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalJapanese Journal of Thoracic Diseases
Volume34
Issue numberSUPPL.
Publication statusPublished - 1996

Keywords

  • Adhesion molecule
  • Airway epithelial cell
  • Cytokine
  • Rhinovirus

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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