Revolving Vernier Mechanism Controls Size of Linear Homomultimer

Takeo Uchida, Keita Abe, Yuma Endo, Shosei Ichiseki, Satoru Akita, Shiyun Liu, Sho Aradachi, Masataka Saito, Akihiko Fukuchi, Taiyo Kikkawa, Theo Dammaretz, Ibuki Kawamata, Yuki Suzuki, Shin ichiro M. Nomura, Satoshi Murata

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A new kind of the Vernier mechanism that is able to control the size of linear assembly of DNA origami nanostructures is proposed. The mechanism is realized by mechanical design of DNA origami, which consists of a hollow cylinder and a rotatable shaft in it connected through the same scaffold. This nanostructure stacks with each other by the shape complementarity at its top and bottom surfaces of the cylinder, while the number of stacking is limited by twisting angle of the shaft. Experiments have shown that the size distribution of multimeric assembly of the origami depends on the twisting angle of the shaft; the average lengths of the multimer are decamer, hexamer, and tetramer for 0°, 10°, and 20° twist, respectively. In summary, it is possible to affect the number of polymerization by adjusting the precise shape and movability of a molecular structure.

Original languageEnglish
Article number1702158
JournalSmall
Volume13
Issue number41
DOIs
Publication statusPublished - 2017 Nov 6

Keywords

  • DNA nanotechnology
  • DNA origami
  • Vernier mechanism
  • linear homomultimer
  • self-assembly

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)
  • Engineering (miscellaneous)

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  • Cite this

    Uchida, T., Abe, K., Endo, Y., Ichiseki, S., Akita, S., Liu, S., Aradachi, S., Saito, M., Fukuchi, A., Kikkawa, T., Dammaretz, T., Kawamata, I., Suzuki, Y., Nomura, S. I. M., & Murata, S. (2017). Revolving Vernier Mechanism Controls Size of Linear Homomultimer. Small, 13(41), [1702158]. https://doi.org/10.1002/smll.201702158