Revisions to the Xenopus gastrula fate map: Implications for mesoderm induction and patterning

Gaku Kumano, William C. Smith

Research output: Contribution to journalReview articlepeer-review

31 Citations (Scopus)

Abstract

A revised fate map of the gastrula Xenopus embryo predicts the existence of patterning mechanisms that operate within the animal/vegetal axis of the mesoderm-forming marginal zone. We review here molecular and embryologic data that demonstrate that such mechanisms are present and that they operate independently of the Spemann organizer. Evidence suggests that polarized fibroblast growth factor activity in the animal/vegetal axis patterns this axis. We present a model of mesoderm induction and patterning that integrates the new data on Spemann organizer-independent animal/vegetal patterning with data on other inductive pathways known to act on the gastrula marginal zone.

Original languageEnglish
Pages (from-to)409-421
Number of pages13
JournalDevelopmental Dynamics
Volume225
Issue number4
DOIs
Publication statusPublished - 2002 Dec 1
Externally publishedYes

Keywords

  • Animal/vegetal
  • Blood
  • Fibroblast growth factor
  • Induction
  • Mesoderm
  • Patterning
  • Three-signal model
  • Xenopus

ASJC Scopus subject areas

  • Developmental Biology

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