Review: The regulation of tooth development and morphogenesis

Takashi Nakamura; Yoshihiko Yamada; Satoshi Fukumoto

doi:10.1007/978-4-431-54070-0_3

Review: The regulation of tooth development and morphogenesis

Takashi Nakamura, Yoshihiko Yamada, Satoshi Fukumoto

DEN - Dental Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Citations (Scopus)

Abstract

A variety of vertebrate organs, including teeth, begins their development by inductive sequential and reciprocal interactions between epithelium and mesenchyme. In tooth development, the interactions between ectodermal-derived epithelium and the cranial neural crest-derived mesenchyme regulate the shape, position, and size of the tooth crown with a functional cusp. During tooth development, many signaling molecules and transcription factors regulate tooth development and morphogenesis. Recently, we reported Epiprofin, an Sp transcription factor, is expressed during tooth development and exerts critical roles in dental epithelial differentiation and the determination of tooth number. In this review, we describe the expression pattern and functions of Epiprofin in tooth development.

Original language	English
Title of host publication	Interface Oral Health Science 2011
Publisher	Springer Japan
Pages	14-21
Number of pages	8
ISBN (Electronic)	9784431540700
ISBN (Print)	9784431540694
DOIs	https://doi.org/10.1007/978-4-431-54070-0_3
Publication status	Published - 2012 Jan 1

Keywords

Epiprofin
Supernumerary teeth
Tooth development
Tooth morphogenesis

ASJC Scopus subject areas

Dentistry(all)

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10.1007/978-4-431-54070-0_3

Cite this

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AU - Yamada, Yoshihiko

AU - Fukumoto, Satoshi

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AB - A variety of vertebrate organs, including teeth, begins their development by inductive sequential and reciprocal interactions between epithelium and mesenchyme. In tooth development, the interactions between ectodermal-derived epithelium and the cranial neural crest-derived mesenchyme regulate the shape, position, and size of the tooth crown with a functional cusp. During tooth development, many signaling molecules and transcription factors regulate tooth development and morphogenesis. Recently, we reported Epiprofin, an Sp transcription factor, is expressed during tooth development and exerts critical roles in dental epithelial differentiation and the determination of tooth number. In this review, we describe the expression pattern and functions of Epiprofin in tooth development.

KW - Epiprofin

KW - Supernumerary teeth

KW - Tooth development

KW - Tooth morphogenesis

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BT - Interface Oral Health Science 2011

PB - Springer Japan

ER -

Review: The regulation of tooth development and morphogenesis

Abstract

Keywords

ASJC Scopus subject areas

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