Abstract
Background/Aim: Methionine addiction, a fundamental and general hallmark of cancer, is due to the excess use of methionine for transmethylation, and is described as the Hoffman-effect. Methionine-addicted cancer cells can revert at low frequency to methionine independence when selected under methionine-restriction. We report here that highly-malignant methionine-addicted H460 human lungcancer cells, when selected for methionine independence, have greatly-reduced tumorigenic potential. Materials and Methods: Methionine-addicted H460 parental cancer cells and methionine-independent revertant H460-R1 cells were injected in nude mice subcutaneously. Results: When the parental H460 methionine-addicted cells were injected in nude mice at 2.5×105, 1×105and 5×104, the cells could form tumors. In contrast, the H460-R1 methionine-independent revertant cells could not form tumors when the above-listed cell numbers were injected in nude mice. Conclusion: There is a tight linkage between methionine addiction and malignancy.
Original language | English |
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Pages (from-to) | 641-643 |
Number of pages | 3 |
Journal | Anticancer research |
Volume | 41 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2021 Feb |
Externally published | Yes |
Keywords
- Cancer
- H460
- Lung cancer
- Methionine addiction
- Methionine independence
- Reversion
- Tumorigenicity
ASJC Scopus subject areas
- Oncology
- Cancer Research