Reversible Gel–Sol Transition of a Photo-Responsive DNA Gel

Daisuke Kandatsu, Keitel Cervantes-Salguero, Ibuki Kawamata, Shogo Hamada, Shin ichiro M. Nomura, Kenzo Fujimoto, Satoshi Murata

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Stimuli-responsive DNA gels that can undergo a sol-gel transition in response to photo-irradiation provide a way to engineer functional gel material with fully designed DNA base sequences. We propose an X-shaped DNA motif that turns into a gel by hybridization of self-complementary sticky ends. By embedding a photo-crosslinking artificial base in the sticky-end sequence, repetitive gel–sol transitions are achieved through UV irradiation at different wavelengths. The concentration of the DNA motif necessary for gelation is as low as 40 μm after modification of the geometrical properties of the motif. The physical properties, such as swelling degree and diffusion coefficient, were assessed experimentally.

Original languageEnglish
Pages (from-to)1118-1121
Number of pages4
JournalChemBioChem
DOIs
Publication statusPublished - 2016 Jun 16

Keywords

  • DNA
  • DNA structures
  • gels
  • nanotechnology
  • photo-responsive DNA

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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