Retrospective analysis of concurrent chemoradiation with the combination of bleomycin, ifosfamide and cisplatin (BIP) for uterine cervical cancer

Michiko Aoki, Jun Ichi Akahira, Hitoshi Niikura, Sumika Saito, Yoriko Abe, Takeshi Aida, Naoka Sato, Takako Kitamura, Kenro Otsuki, Atsuko Katahira, Hiroki Utsunomiya, Chikako Okamura, Tadao Takano, Kiyoshi Ito, Kunihiro Okamura, Nobuo Yaegashi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Combination chemotherapy consisting of bleomycin, ifosfamide, and ciplatin (BIP) is recognized as one of the most effective chemotherapies for uterine cervical cancer. However, there have been no reports that evaluate concurrent use of radiation with BIP. The objective of this study was to evaluate the toxicity and response of the combination of BIP concurrent with radiation in patients with squamous cell carcinoma of the uterine cervix. Eligibility criteria included patients who underwent radical hysterectomy (Type III hysterectomy) as a primary treatment and revealed lymph node metastases or deep myometrial invasion (stage IB and IIA) and patients who were previously untreated (stage IIB-IV). All of the patients had biopsy-proven squamous cell carcinoma of the uterine cervix. The patients received three courses of BIP chemoradiation, and the response and toxicity were evaluated. From January 2000 to December 2003, 30 patients met study eligibility criteria. All but three patients completed 3 courses of planned chemotherapy. The frequency of severe (grade 3 and 4) toxicity was as follows: anemia, 46.7%; neutrocytopenia, 73.3%; thrombocytopenia, 16.7%; and nausea and vomiting, 23.3%. Among 30 patients, 22 cases were evaluated for response. Complete response was achieved in 16 (72.7%) of patients, with a response rate of 90.9%. In conclusion, BIP chemoradiation seems to be superior to previously reported chemoradiation regimens, and has a potential as an optimal combination chemotherapy concurrent with radiation.

Original languageEnglish
Pages (from-to)309-315
Number of pages7
JournalTohoku Journal of Experimental Medicine
Volume204
Issue number4
DOIs
Publication statusPublished - 2004 Dec

Keywords

  • BIP
  • Cervical carcinoma
  • Chemoradiation
  • Clinical trial

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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