Restricted replication-competent adenovirus: A novel strategy for cancer gene therapy

Makoto Sunamura, Fuyuhiko Motoi, Seiki Matsuno

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Mutant adenoviruses that are selectively replication- competent in tumor cells have been developed as a novel strategy for gene therapy of cancer. Such selectively replicating viruses may overcome the limitations of the gene transfer of adenoviral vectors. The replication of such viruses in a small fraction of the tumor cells leads to amplification and extension of the antitumor effect, with cell killing being caused exclusively by viral replication and cell lysis. Replication-competent adenoviruses have several theoretical advantages over replication-defective adenoviruses for cancer gene therapy. It has been demonstrated that replication-competent adenoviruses are not only a strong weapon themselves but that they are also useful carriers of genes for anti-tumor factors, acting as virus vectors specific to tumors without normal p53 function or an intact retinoblastoma gene (RB) pathway. Clinical trials will clarify these advantages in future.

Original languageEnglish
Pages (from-to)147-152
Number of pages6
JournalInternational Journal of Clinical Oncology
Volume5
Issue number3
DOIs
Publication statusPublished - 2000 Jun

Keywords

  • Adenovirus
  • Gene therapy
  • P53
  • RB
  • Replication-competent

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology

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